ENU injected into male mice introduces point mutations that are transferred through the germ line. Offspring of such mice carry a variety of random, and unique, mutations. Dominant mutations are expressed directly in these offspring while recessive mutations can be uncovered by further breeding. The programme is currently generating approximately 240 mice for dominant screens and 24 adult and embryonic recessive pedigrees a month for a broad phenotypic screen. Subsequently, we use genetic mapping strategies to identify the mutation and the gene involved. The gene then acts as an entry point to analyse the genetic and biochemical pathway. We welcome enquires about the development of new screens, phenotyping platforms and mutagenesis platforms.
Please visit our phenotyping section of the website