ENU DNA Archive
MRC Harwell has been at the forefront of studies of gene function using both phenotype-driven and genotype-driven ENU mutagenesis. Chemical mutagenesis with ENU produces a wide range of possible functional changes, including hypomorphs, antimorphs and gain-of-function or neomorphs. This complements and expands upon the typical result of gene inactivation by homologous recombination ("knockouts"), which usually result in non-functional or null alleles. These additional alleles can be invaluable in revealing previously unknown aspects of gene function.
The current archive consists of over 10,000 DNA samples from individual F1 ENU mutagenised mice paralleled by frozen sperm samples. This archive continues to grow.
MRC Harwell welcomes requests from academic researchers to access the DNA archive and after successful screening, requests for mutant mice.
Read more about the ENU DNA Archive