Mouse Models of Disease: Improving Reproducibility of Pathology Endpoints in Challenge Models
Wellcome Trust Advanced Courses and Scientific Conferences
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
9-11 February 2016
Lack of reproducibility in biomedical science, particularly mouse model analyses, is thought to be hindering advances in our understanding of human disease and development of novel therapies. The use of best practices in mouse model histopathology can aid reproducibility, and reduce animal usage, by ensuring that accurate data is generated from mouse models taking into account confounding factors such as background pathology, the effects of genetic manipulation and the potential effects of the animal’s environment and experimental challenges.
This three-day meeting is aimed at veterinary and human pathologists and scientists working with mouse models in academic and industrial research. The first day of the meeting will review basic approaches to creating and interpreting reproducible mouse pathology data. Days two and three will discuss the use of pathology and allied techniques in investigating pathology in the respiratory and gastrointestinal tracts in challenged and non-challenged phenotyping studies. Throughout the programme an emphasis will be placed on understanding the influence of environmental effects and experimental challenges on pathology endpoints and their potential effects on the reproducibility of data.