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Globally, the number of people living with diabetes has almost quadrupled since 1980. Type 2 diabetes accounts for approximately 90% of these cases and represents a significant and growing health burden on people and society.

Treatments are available but they are not always effective, we are trying to understand the genetics of the disease in order to identify new therapeutic targets.

Large scale human genetic studies have identified many genetic loci implicated in diabetes and obesity. Our aim is to study these genes more closely in mice and find out more about the basic physiology and biology, this may ultimately be translatable for therapeutic benefit.