With an interest in neuromuscular function and ataxia, MRC Harwell has a range of sophisticated equipment for measuring various subtle aspects of muscle co-ordination, analysis of gait and also assess changes in muscle tone. Through a combination of tests, combined with behavioural studies as well, we able to build a broad picture of the neuromuscular system within a genetically altered line.
We have a range of equipment for assessing activity. This includes the Phenomaster Wheel Running set up, where mice are singly housed for a period of time from one night up to three weeks in a cage with a wheel. After a period of time acclimatising to the presence of the wheel, it is changed for one with fewer rungs and altered gaps between the rungs, presenting a significant challenge to the mice.