Specialised investigations help uncover and characterise new mouse models of human genetic disease
Mice identified in dysmorphology, sensory and metabolism phenotypic screens are investigated to describe the underlying pathology. A number of approaches are used including necropsy and organ histology. These specialised investigations help uncover and characterise new mouse models of human genetic disease.
We have a fully trained and experienced team who can provide training on- or off-site for:
- Full tissue dissection (necropsy) for primary phenotyping screens
- Specific tissue dissections and techniques
- Perfusion of animals/tissues
- Collection of fixed and frozen tissues
We can provide advice and assistance on:
- Pathological screen of mouse tissues
- Development of protocols for pathology endpoints
- Advice on selection, fixing and processing of tissues
Diagnostic pathology is used in conjunction with sentinel health screening to assure high health status of our mouse colonies. We are compliant with European Federation of European Laboratory Animal Science Association standards, The Association for Assessment and Accreditation of Laboratory Animal Care International (aaalac) and ISO9001 certification. This ensures high welfare standards for the mice and rigorous biological standardisation to ensure the highest quality research results.
If you require any further assistance or information please contact the necropsy team using the contact details listed. Alternatively please submit a request form for any planned work.
We have well established links to professional veterinary pathology services.
The Necropsy team can provide training in a variety of pathology based techniques and procedures.
- Basic default necropsy
- Standard full tissue list necropsy*
- Specific tissue dissection*
- Whole body vasculature perfusion
- Standard full tissue list cut-in and processing*
- Blood Collection
- Cryopreservation of tissues
* All of these training options are currently offered as part of the Necropsy interactive two day training course
If training is required please contact the Necropsy team to discuss an appropriate time for training.