Remya Raghavan Nair

Biography & Research interests

My experience with genetically modified mouse models began during my lab experiments as part of my PhD course done under the supervision of Prof.Kalervo Hiltunen in the Faculty of Biochemistry & Molecular Medicine at the University of Oulu, Finland. My PhD project was to study the physiological roles of mitochondrial fatty acid synthesis in eukaryotes where I have been working predominantly on genetically modified mouse models in addition to yeast models to some extent. After completing my PhD, I moved to the UK to start the next stage of my career as a post-doctoral training fellow in Prof. Lizzy Fisher and Dr. Thomas Cunningham’s lab at MRC Harwell Institute. My current research project seeks to generate a physiological mouse model to study the pathogenesis mechanism of amyotrophic lateral sclerosis (ALS) caused by mutations in C9orf72 gene. Apart from that, I am involved in characterizing other bespoke mouse models of neurodegeneration that were generated in our lab.

Current Projects

  1. Physiological mouse models of ALS
  2. Pathogenesis mechanisms of neurodegeneration in bespoke mouse models

Selected Publications

Remya R. Nair, Silvia Corrochano, SamantaGasco, Charlotte Tibbit, David Thompson, Abraham Acevedo Arozena, Pietro Fratta, Thomas J. Cunningham, Elizabeth M.C. Fisher. Uses for humanised mouse models in precision medicine for neurodegenerative disease. Mammalian Genome, DOI: https://doi.org/10.1007/s00335-019-09807-2. 2019

Fei Zhu, Remya R. Nair, Elizabeth M.C. Fisher and Thomas J. Cunningham. Humanising the mouse genome, piece by piece. Nature Communications, DOI: https://doi.org/10.1038/s41467-019-09716-7. 2019

Remya R. Nair, Henna Koivisto, Kimmo Jokivarsi, Ilkka J. Miinalainen, Kaija J. Autio, Aki Manninen, HeikkiTanila, J. KalervoHiltunen and Alexander J. Kastaniotis. Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice. Journal of Neuroscience:38(45): Pp 9781–9800. 2018

PrasanthSivakumar, Francesca De Giorgio, AgnieszkaUle, Jacob Neeves, Remya R. Nair, Matthew Bentham, Nicol Birsa, Jack Humphrey, Vincent Plagnol, Abraham Acevedo-Arozena, Thomas J. Cunningham, Elizabeth M.C. Fisher and Pietro Fratta. TDP-43 mutations increase HNRNPA1-7B through gain of splicing function. Brain: 141 (12), DOI: https://doi.org/10.1093/brain/awy260. 2018

Remya R. Nair, Juha M. Kerätär, Mikko A. J. Finnilä, Helena I. Autio-Harmainen, Ilkka J. Miinalainen, Pentti A. Nieminen, J. Kalervo Hiltunen and Alexander J. Kastaniotis. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Human Molecular Genetics: 26(11): Pp 2104-2117. 2017

Alexander J. Kastaniotis, Kaija J. Autio, Juha M. Kerätär, Geoffray Monteuuis, Anne M. Mäkelä, Remya R. Nair, Laura P. Pietikäinen, Antonina Shvetsova, Zhijun Chen and J. Kalervo Hiltunen. Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology. BBA Molecular and Cell Biology of Lipids: 1862(1): Pp 39-48. 2017

Eija M. Selkälä, Remya R. Nair, Werner Schmitz, Ari-Pekka Kvist, Myriam Baes, J. Kalervo Hiltunen and Kaija J. Autio. Phytol is lethal for Amacr- deficient mice. BBA – Molecular and Cell Biology of Lipids: 1851(10): Pp 1394-405. 2015

Kaija J. Autio, Werner Schmitz, Remya R. Nair, Eija M. Selkälä, Raija T. Sormunen, Ilkka J. Miinalainen, Myriam Baes and J. Kalervo Hiltunen.Role of α-Methylacyl-CoA Racemase (Amacr) and peroxisomal Multifunctional Enzyme 1 (Mfe-1) in bile acid synthesis in mice. Biochemical Journal: 461(1): Pp 125-35. 2014

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