Dr. Vrinda Sreekumar

Biography & Research interests

Following my PhD at the University of Tuebingen, Germany, I was involved in a project investigating the factors affecting osteogenic differentiation of mesenchymal stem cells, where I stumbled upon the role of primary cilia in cells. I realised primary cilia to be a critical determinant of cellular differentiation and since then I have been greatly intrigued with its role in development, cellular signalling and disease. Soon I joined Vertex pharmaceuticals ltd (UK) as a research scientist to investigate Autosomal dominant polycystic kidney disease, a classic ciliopathy. After a yearlong research in industry, I sought out to seek the disease mechanisms of ADPKD which revolved around the Polycystins and its interactions. Mouse genetics unit at MRC Harwell attracted as a great platform to expand my understanding of the disease, where I currently work as a Postdoctoral training fellow investigating the mouse model of ADPKD. During my 4 year Postdoc programme here at MGU, I am hoping to widen my knowledge and expertise in the field of ciliopathies.

Current Projects

  1. Investigating mouse model of ADPKD.
  2. Evaluating the interactions between PC2 – PC1L1 versus PC2 – PC1 and its role in development and disease.

Selected Publications

Cilia and Development. Curr opin Genet Dev 2019. Vrinda Sreekumar and Norris DP.

Exogenous Delivery of Link N mRNA into Chondrocytes and MSCs-The Potential role in Increasing anabolic Response. Int J Mol Sci 2019. Gauri Tendulkar, Vrinda Sreekumar et al.

Ciliary exclusion of Polycystin 2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. Nature communications 2019 (in press). Rebecca Walker, Jennifer Keynton, Daniel Grimes, Vrinda Sreekumar et al.

Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity contributing to the impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke. OxiMed Cell Longev 2018. Romina Aspera, Vrinda Sreekumar et al.

Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus. Sci Rep 2018. Gauri tendulkar, Vrinda Sreekumar et al.

Resveratrol protects primary cilia integrity of human mesenchymal stem cells from cigarette smoke to improve osteogenic differentiation in vitro. Arch Toxicology 2017. Vrinda Sreekumar et.al.

TGF-ß1 impairs mechanosensation of human osteoblast via HDAC6-mediated shortening and distortion of primary cilia. Journal of Molecular medicine 2017. Sabrina Ehnert, Vrinda Sreekumar; Rominao H. Aspera-Werz et.al.

BMP9 a possible alternative drug for recently withdrawn BMP7? New presprectvie for (re-) implementation by personalised medicine. Archives of Toxicology 2016. Sreekumar V, Aspera-Werz RH et. al.

Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson’s disease model. Plos One 2013. Zhu JY, Vereshchagina N, Sreekumar V et al.

Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in HSP drosophila model. Plos Genet 2012. Füger P*, Sreekumar V*, Rasse TM, et. al. (*contributed equally)