Latest MRC Harwell News

View the latest news stories to come out of MRC Harwell.

Humanising mice to enable modelling of neurodegenerative diseases

Generation of the first genomically humanised mice in which human genes for ALS/FTD-associated genes replace their mouse orthologues Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by progressive loss of muscle control, leading to spreading paralysis and death typically within five years of diagnosis. Understanding of the disease is limited and it is […]

Paige Street receives MRC Max Perutz Science Writing Award commendation

Mammalian Genetics Unit PhD student Paige Street is commended for their article, Schizophrenia – the gene ‘keeping it in the family’ Paige Street, a PhD student in the Neurobehavioural Genetics group at MRC Harwell, has received a commendation for their article submitted to the MRC’s 2021 Max Perutz Science Writing Award. The award, named after […]

Identification of mammalian proteins that allow sperm to move and lungs to be kept clear of fluid

An atomic model of a doublet microtubule from mammalian respiratory cilia provides a framework to understand how these proteins allow cilia function and how mutations could cause disease Our lungs are kept clear of fluid through the action of waving cilia; small hair-like cellular projections that move in a rhythmic manner. In fact, these motile […]

Analysis of a mouse model of Down syndrome that shows many disease-associated effects

Comprehensive phenotypic analysis of a mouse model that replicates the majority of the gene dosage increase in Down syndrome Down syndrome is a complex condition affecting many tissues throughout the body and is the most common genetic cause of intellectual disability, Alzheimer’s disease, and heart defects. However, there are no effective treatments for most of […]