Bespoke Mouse Models for Your Research

Submit an application to have your free, novel, genetically altered mouse model generated by the Mary Lyon Centre

The GEMM Call is currently open. The call deadline is in:

Submit an Application Today

Call Deadline: 15th September 2024

Genome Editing Mice for Medicine (GEMM)

This GEMM call is dedicated to RARE DISEASES *

The MRC has committed resources to generating free novel genetically altered mouse strains to be used in vital biomedical research by the UK scientific community.

We are welcoming applications for the generation of mutant mouse models for research on rare diseases where other models such as in vitro or in silico have been exhausted.
The call is open to requests for any type of edited or engineered alleles.
Please do not hesitate to get in touch with the GEMM team ( for support in designing mutations and any other questions you may have regarding your application.

*Conditions which affect fewer than 1 in 2,000 people


109 Novel Lines Generated

The GEMM Call

The UK academic research community is invited to nominate ideas and designs for new mouse models. Nominations will be assessed by a cross-disciplinary group of experts across two key themes:

  1. The nominator’s own research hypotheses and specific research plans for utilising the mouse
  2. The beneficial impact that generation of the proposed novel mouse line will have on the wider academic community

View this guide to see how to submit an application.

GEMM offers a comprehensive genome engineering service that can meet researchers’ specific requirements

The GEMM programme can:

  • Create a wide variety of mutant alleles.
  • Create extensively validated mouse lines by delivering reagents into embryonic stem cells or directly into the embryo.
  • Develop new approaches for challenging projects to ensure we meet the demand for novel mutant mouse lines.
  • Manipulate the mouse genome in a number of diverse genetic backgrounds.

Global Accessibility

The GEMM programme aims to not only facilitate the generation of novel mouse models, but also ensure access to these models for the research community. As such, successfully generated mouse lines will be made publicly available through the European Mouse Mutant Archive (EMMA), one of the world’s leading mouse repositories.

View all lines on EMMA

The Application Process

A panel will evaluate applications against the following broad criteria, noting that the focus of the individual proposal may vary depending on the experimental work proposed and the details of the lines generated:

Biomedical Importance

Strength of Application

Community Value

Cost / Benefit

Alternative to a Mouse Model

For any enquiries please contact