Characterisation through embryonic development and early life
With developmental diseases being so varied in their effects, we will tailor our analysis to your specific disease of interest.
Our Embryo Phenotyping team harvest litters at stages relevant to the disease model and can define windows of viability for those models. They can also capture embryo morphology and have extensive experience with analysing anatomy and dysmorphology in embryos ranging from E9.5 to E18.5.
For a comprehensive insight into any developmental disease model, it is likely that we would use our Home Cage Analysis system in which we are able to observe behaviour and movement of mice in their home cage automatically without experimenter intervention. This complements individual short-term assays that can be used to investigate metabolism, neurological function, vision, hearing, and other characteristics. For more information, please visit the In Vivo Phenotyping page.
We also offer a wide range of clinical chemistry and haematology tests that might be suitable for the study of developmental diseases that affect the blood cells or metabolism. For more information, please see the Clinical Chemistry page.
If you are looking to generate a new genetic mouse model of a developmental disease, we can support you with this process, whether your project requires simple deletions or point mutations or generation of more complex alleles.