International Mouse Phenotyping Consortium

The International Mouse Phenotyping Consortium (IMPC) is a global project to determine the function of every protein-coding gene in the mouse genome. The IMPC is a global effort comprised of scientists from 18 research institutions across 11 different countries.

The IMPC’s aim is to generate a null mutation for every gene in the mouse genome.

This is done essentially by switching off a gene and then looking to see if there are any abnormalities in the mouse, thus helping to decipher the function of the gene. Broad-based phenotyping data is obtained for each mutation, this information is then freely disseminated to the scientific community via the IMPC website.

The MRC Harwell Institute is the data coordination centre for the IMPC. Data from all over the world is quality checked here before being made available online. MRC Harwell is also a phenotyping centre for the IMPC.