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The INFRAFRONTIER (www.infrafrontier.eu) consortia aims to build a world-class research infrastructure that provides the biomedical research community with the tools needed to better understand the role of gene function in human disease. To achieve this goal, the consortium uses the mouse as the model organism of choice.

Partners

INFRAFRONTIER is comprised of 23 partners, which include:

  • Mouse clinics from Europe and Canada
  • EMMA Archiving and Distribution Nodes
  • European Bioinformatics Institute (EMBL-EBI)

The INFRAFRONTIER mission

  • INFRAFRONTIER will shape the European Research Area in the field of mouse functional genomics and thereby make an important contribution to the study of human disease.
  • INFRAFRONTIER will set standards for systemic phenotyping of mouse models and for archiving and distribution of mouse mutants in Europe.
  • INFRAFRONTIER will offer the highest-quality services and cutting-edge technologies provided by the leading labs in Europe.
  • INFRAFRONTIER will disseminate knowledge by state-of-the-art training courses.

Objectives

  • To provide access to mouse models, data, scientific platforms and services to study the functional role of the genome and relate it to human health and disease.
  • To provide an archiving and distribution service for scientifically valuable mouse strains through the European Mouse Mutant Archive (EMMA), one of the world’s leading mouse repositories.
  • To provide access to systemic genotype-phenotype analysis using cutting-edge analytical and diagnostic methodologies in the INFRAFRONTIER mouse clinics.
  • To provide distribution capacities for large-scale international initiatives such as the International Mouse Phenotyping Consortium (IMPC: www.mousephenotype.org).

Services

  • Free archiving of mouse models Free systemic phenotyping of mouse models
  • Free mouse production from ES cells
  • Free late-onset systemic (aging) phenotyping
  • World-wide distribution service
  • Access to the NKI-GEMM-ESC (Netherlands Cancer Institute embryonic stem cells derived from genetically engineered mouse models of cancer) archive
  • Axenic (germ-free) mouse services
  • For-profit access to EUCOMM knockout models
  • Training in cryopreservation, phenotyping and new model development