National Mouse Genetics Network

The MRC is investing more than £20m in a major new national network in mouse genetics for disease modelling to accelerate our understanding of human disease and improve diagnosis and treatments.

The National Mouse Genetics Network will bring together a package of distinctive research clusters across the UK and long-term partnership with the Mary Lyon Centre (MLC).

The Network, led by National Director Professor Owen Sansom, will capitalise on the UK’s international excellence in mouse and human genetics, and wider biomedical sciences. The new investment will comprise a small number of distributed research clusters pursuing distinctive, but complementary, challenge-led research and will be embedded within UK research organisations. The Network will include a new Harwell research cluster, co-located with the Mary Lyon Centre, that will capitalise on the specific interdisciplinary opportunities on the Harwell campus. All clusters will draw directly from the specialist facilities and capabilities of the Mary Lyon Centre (including genome-engineering, phenotyping and animal care) to deliver their science ambitions.

National Mouse Genetics Network timeline. We are in the cluster selection phase

Network Mission

The Network will provide an attractive platform for industry engagement at a time when the life sciences sector is seeking better predictive models for drug and therapeutic development.

The mission of the Network will be to drive:

  1. The integration of mouse genetics, cell and tissue systems and deep phenotyping with human / clinical genomics and pathology in centres of excellence across the UK
  2. National partnerships and coordination within and between disease/thematic science areas to help tackle the major challenges and national ambitions in priority disease areas
  3. The open science and 3Rs agendas by optimising the production, archiving and availability / sharing of mouse resources and data for national use through the Mary Lyon Centre

The Mary Lyon Centre

The Mary Lyon Centre (MLC) will act as a national facility hub providing world-class expertise, tools, resources, and specialist technologies and services not readily available elsewhere. It will act as a central repository for, and provider of, the genetically engineered mice and associated data delivered through its own phenotyping platforms and those of the clusters. The MLC will manage the distribution of mouse models to the wider national and international communities and will also act as a national training hub to support specialist skills and capacity needs. Whilst the MLC will establish new partnerships with the research clusters, it will continue its core business of providing specialist services to the wider UK academic and industry mouse research communities including, genome engineering, advanced phenotyping and cryopreservation.

Expression of Interest Call

Research Clusters

The distributed cluster investments will provide a platform to support ambitious, multi-dimensional and thematically-focused research that brings together mouse genetics with complementary capabilities across human, cell, tissue and in silico systems. Their core investment will be focused on addressing the critical needs of the relevant theme, and will be enhanced through grant support won in open competition. The Harwell cluster co-located with the Mary Lyon Centre will capitalise on the specific, interdisciplinary opportunities on the wider Harwell campus.

Call Now Closed

The clusters expression of interest call is now closed.

The panel assessment will take place in March/April 2021 followed by a workshop for successful applicants on 20th May 2021.

Expressions of Interest Call
Opportunity Status:
Funding Type:
Opening Date:
10 February 2021 10:00 am
Closing Date:
24 March 2021 4:00 pm

Call Now Closed