MRC Harwell is at the international forefront of the use of mouse genetics to study the relationship between genes and disease. The models we create and study are used to understand the disease processes that occur when a gene goes wrong.
Sex reversal defect explained
Expression of the gene Map3k4 has rescued testes development in mice with a type of sex reversal, demonstrating the important role this gene plays in directing the development of the gonads.
Syndrome’s genetic cause identified
A new intellectual disability syndrome has been described in patients. Using a mouse with remarkably similar characteristics, researchers now reveal how mutations in the β-catenin gene could cause it.
IMPC virtues noted by Nature
MRC Harwell is part of the IMPC, a project to create a comprehensive catalogue of mammalian gene function – now a new Nature editorial explains why it’s so important.
Studying mouse embryo development
We are using advanced 3D imaging techniques to track the changes that occur during mouse development and create a 3D 'atlas' of the embryo.