MRC Harwell Institute


The Advance Team
+44 (0)1235 841438


20 Sep 2021 - 21 Sep 2021


9:30 am - 5:00 pm


£500 per person (VAT exempt)

Advanced Mouse Genetics

For: Colony Managers and Researchers

This course will cover more complex genetics including multiple allele crosses and will inform breeding strategies and experimental design rather than give a complete guide to the molecular biology. We will examine how to plan breeding schemes, how to identify appropriate controls and analyse recombinase (Cre) expression.

After the course, you will be able to:

  • Predict the outcomes of genetic crosses
  • Understand the fundamentals of mouse genetic engineering
  • Have a working knowledge of the genetic background of mouse strains
  • Understand how to maintain the genetic integrity of inbred lines
  • Perform multiple allele inheritance calculations
  • Understand how Genetically Altered lines can be established from modern transgenic technologies
  • An understanding of the basic principles of conditional mutagenesis
  • Practical experience in setting up breeding programmes for conditional mutagenesis, including the choice of appropriate control cohorts

Hourly Schedule

Day 1

10:00 - 10:30
Registration, Orientation, Coffee, Icebreaker and H&S
10:30 - 12:30
Session 1
12:30 - 13:00
13:00 - 14:00
Session 2
14:00 - 14:45
Session 3
14:45 - 15:00
Tea and coffee break
15:00 - 16:30
Session 4
16:00 - 17:00
Tour (optional)
Mary Lyon Centre

Day 2

09:00 - 10:30
Session 4
10:30 - 11:00
Tea and coffee break
11:00 - 12:30
Session 5
12:30 - 13:00
13:00 - 14:30
Session 6
14:30 - 14:45
Tea and coffee break
14:45 - 16:30
Session 6

The event is ongoing.

  • Since taking the course last spring I took your advice and have changed the way I am breeding to maintain our colony. This has a huge positive impact on not only the amount of cages in use, cost savings including genotyping, but of course also the 3Rs.

    20th Mar 2019

  • Thank you for the course. It absolutely answered the areas I was looking to know more about. Your in depth knowledge and expertise shone through. Plus, the course delivery was very engaging. I will definitely be recommending the course to my colleagues.

    24th Oct 2019

  • I just wanted to say thank you for the course and it was a pleasure to meet you both. We found the course very useful and informative.

    24th Oct 2019

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