Consortium Papers

Publications detailing the collaborative efforts of the MLC with international consortia involved in the targeted construction and phenotyping of mutant mouse lines, as well as the archiving and distribution of mouse disease models and disease gene discovery. These include the IMPC, EUMODIC and INFRAFRONTIER.

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Elrick, H., Peterson, K. A., Willis, B. J., Lanza, D. G., Acar, E. F., Ryder, E. J., Teboul, L., Kasparek, P., Birling, M. C., Adams, D. J., Bradley, A., Braun, R. E., Brown, S. D., Caulder, A., Codner, G. F., DeMayo, F. J., Dickinson, M. E., Doe, B., Duddy, G., Gertsenstein, M., Goodwin, L. O., Hérault, Y., Lintott, L. G., Lloyd, K. C. K., Lorenzo, I., Mackenzie, M., Mallon, A. M., McKerlie, C., Parkinson, H., Ramirez-Solis, R., Seavitt, J. R., Sedlacek, R., Skarnes, W. C., Smedley, D., Wells, S., White, J. K., Wood, J. A., Murray, S. A., Heaney, J. D., Nutter, L. M. J.

(2024) , Sci Rep , 14 , 22626

10.1038/s41598-024-72418-8

PMC11443006

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The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease

Groza, T., Gomez, F. L., Mashhadi, H. H., Muñoz-Fuentes, V., Gunes, O., Wilson, R., Cacheiro, P., Frost, A., Keskivali-Bond, P., Vardal, B., McCoy, A., Cheng, T. K., Santos, L., Wells, S., Smedley, D., Mallon, A. M., Parkinson, H.

(2023) , Nucleic Acids Res , 51 , D1038-D1045

10.1093/nar/gkac972

PMID: 36305825

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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Chee, J. M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Chin, H. G., Dickinson, M. E., Hsu, C. W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Mammano, F., Nutter, L. M. J., Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K. C. K., Westerberg, H., Moshiri, A.

(2023) , BMC Biol , 21 , 22

10.1186/s12915-022-01475-0

PMC9898963

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Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice

Oestereicher, M. A., Wotton, J. M., Ayabe, S., Bou About, G., Cheng, T. K., Choi, J. H., Clary, D., Dew, E. M., Elfertak, L., Guimond, A., Haseli Mashhadi, H., Heaney, J. D., Kelsey, L., Keskivali-Bond, P., Lopez Gomez, F., Marschall, S., McFarland, M., Meziane, H., Munoz Fuentes, V., Nam, K. H., Nichtová, Z., Pimm, D., Bower, L., Prochazka, J., Rozman, J., Santos, L., Stewart, M., Tanaka, N., Ward, C. S., Willett, A. M. E., Wilson, R., Braun, R. E., Dickinson, M. E., Flenniken, A. M., Herault, Y., Lloyd, K. C. K., Mallon, A. M., McKerlie, C., Murray, S. A., Nutter, L. M. J., Sedlacek, R., Seong, J. K., Sorg, T., Tamura, M., Wells, S., Schneltzer, E., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., White, J. K., Spielmann, N.

(2023) , Mamm Genome , 34 , 180-199

10.1007/s00335-023-09995-y

37294348

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Mendelian gene identification through mouse embryo viability screening

Cacheiro, P., Westerberg, C. H., Mager, J., Dickinson, M. E., Nutter, L. M. J., Muñoz-Fuentes, V., Hsu, C. W., Van den Veyver, I. B., Flenniken, A. M., McKerlie, C., Murray, S. A., Teboul, L., Heaney, J. D., Lloyd, K. C. K., Lanoue, L., Braun, R. E., White, J. K., Creighton, A. K., Laurin, V., Guo, R., Qu, D., Wells, S., Cleak, J., Bunton-Stasyshyn, R., Stewart, M., Harrisson, J., Mason, J., Haseli Mashhadi, H., Parkinson, H., Mallon, A. M., Smedley, D.

(2022) , Genome Med , 14 , 119

10.1186/s13073-022-01118-7

PMC9563108

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