Consortium Papers

Publications detailing the collaborative efforts of the MLC with international consortia involved in the targeted construction and phenotyping of mutant mouse lines, as well as the archiving and distribution of mouse disease models and disease gene discovery. These include the IMPC, EUMODIC and INFRAFRONTIER.

Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

Spielmann, S, Miller, G., Oprea, T.I., et al.

(2022) , Nat Cardiovasc Res , 1 , 157-173

10.1038/s44161-022-00018-8

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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes

Higgins, K., Moore, B. A., Berberovic, Z., Adissu, H. A., Eskandarian, M., Flenniken, A. M., Shao, A., Imai, D. M., Clary, D., Lanoue, L., Newbigging, S., Nutter, L. M. J., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Dickinson, M. E., Dobbie, M., Flicek, P., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Chin, H. G., Mammano, F., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Lloyd, K. C. K., McKerlie, C., Moshiri, A.

(2022) , Sci Rep , 12 , 20791

10.1038/s41598-022-19710-7

PMC9715561

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A resource of targeted mutant mouse lines for 5,061 genes

Birling, M. C., Yoshiki, A., Adams, D. J., Ayabe, S., Beaudet, A. L., Bottomley, J., Bradley, A., Brown, S. D. M., Bürger, A., Bushell, W., Chiani, F., Chin, H. G., Christou, S., Codner, G. F., DeMayo, F. J., Dickinson, M. E., Doe, B., Donahue, L. R., Fray, M. D., Gambadoro, A., Gao, X., Gertsenstein, M., Gomez-Segura, A., Goodwin, L. O., Heaney, J. D., Hérault, Y., de Angelis, M. H., Jiang, S. T., Justice, M. J., Kasparek, P., King, R. E., Kühn, R., Lee, H., Lee, Y. J., Liu, Z., Lloyd, K. C. K., Lorenzo, I., Mallon, A. M., McKerlie, C., Meehan, T. F., Fuentes, V. M., Newman, S., Nutter, L. M. J., Oh, G. T., Pavlovic, G., Ramirez-Solis, R., Rosen, B., Ryder, E. J., Santos, L. A., Schick, J., Seavitt, J. R., Sedlacek, R., Seisenberger, C., Seong, J. K., Skarnes, W. C., Sorg, T., Steel, K. P., Tamura, M., Tocchini-Valentini, G. P., Wang, C. L., Wardle-Jones, H., Wattenhofer-Donzé, M., Wells, S., Wiles, M. V., Willis, B. J., Wood, J. A., Wurst, W., Xu, Y., Teboul, L., Murray, S. A.

(2021) , Nat Genet , 53 , 416-419

10.1038/s41588-021-00825-y

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The Deep Genome Project

Lloyd, K. C. K., Adams, D. J., Baynam, G., Beaudet, A. L., Bosch, F., Boycott, K. M., Braun, R. E., Caulfield, M., Cohn, R., Dickinson, M. E., Dobbie, M. S., Flenniken, A. M., Flicek, P., Galande, S., Gao, X., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Lupski, J. R., Lyonnet, S., Mallon, A. M., Mammano, F., MacRae, C. A., McInnes, R., McKerlie, C., Meehan, T. F., Murray, S. A., Nutter, L. M. J., Obata, Y., Parkinson, H., Pepper, M. S., Sedlacek, R., Seong, J. K., Shiroishi, T., Smedley, D., Tocchini-Valentini, G., Valle, D., Wang, C. L., Wells, S., White, J., Wurst, W., Xu, Y., Brown, S. D. M.

(2020) , Genome Biol , 21 , 18

10.1186/s13059-020-1931-9

PMC6996159

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Human and mouse essentiality screens as a resource for disease gene discovery

Cacheiro, P., Munoz-Fuentes, V., Murray, S. A., Dickinson, M. E., Bucan, M., Nutter, L. M. J., Peterson, K. A., Haselimashhadi, H., Flenniken, A. M., Morgan, H., Westerberg, H., Konopka, T., Hsu, C. W., Christiansen, A., Lanza, D. G., Beaudet, A. L., Heaney, J. D., Fuchs, H., Gailus-Durner, V., Sorg, T., Prochazka, J., Novosadova, V., Lelliott, C. J., Wardle-Jones, H., Wells, S., Teboul, L., Cater, H., Stewart, M., Hough, T., Wurst, W., Sedlacek, R., Adams, D. J., Seavitt, J. R., Tocchini-Valentini, G., Mammano, F., Braun, R. E., McKerlie, C., Herault, Y., de Angelis, M. H., Mallon, A. M., Lloyd, K. C. K., Brown, S. D. M., Parkinson, H., Meehan, T. F., Smedley, D.

(2020) , Nat Commun , 11 , 655

10.1038/s41467-020-14284-2

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