Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study

Raspa, M., Guan, M., Paoletti, R., Montoliu, L., Ayadi, A., Marschall, S., Fray, M., Scavizzi, F.

(2017) , Theriogenology , 96 , 49-57


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Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control

Mianne, J., Codner, G. F., Caulder, A., Fell, R., Hutchison, M., King, R., Stewart, M. E., Wells, S., Teboul, L.

(2017) , Methods , 121 , 68-76


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Intestinal Preparation Techniques for Histological Analysis in the Mouse

Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., Pritchard, D. M.

(2016) , Curr Protoc Mouse Biol , 6 , 148-68


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Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Haeussler, M., Schonig, K., Eckert, H., Eschstruth, A., Mianne, J., Renaud, J. B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., Joly, J. S., Concordet, J. P.

(2016) , Genome Biol , 17 , 148



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Building for the future: essential infrastructure for rodent ageing studies

Wells, S. E., Bellantuono, I.

(2016) , Mamm Genome , 27 , 440-4



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