Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Multi-Photon Microscopy

Sanderson, J.,

(2023) , Curr Protoc , 3 , e634

10.1002/cpz1.634

36706245

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Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease

Bains, R. S., Forrest, H., Sillito, R. R., Armstrong, J. D., Stewart, M., Nolan, P. M., Wells, S. E.

(2023) , Front Behav Neurosci , 17 , 1148172

10.3389/fnbeh.2023.1148172

PMC10073658

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Genotyping Genome-Edited Founders and Subsequent Generation

Mackenzie, M., Fower, A., Allan, A. J., Codner, G. F., Bunton-Stasyshyn, R. K., Teboul, L.

(2023) , Methods Mol Biol , 2631 , 103-134

10.1007/978-1-0716-2990-1_4

36995665

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Excess of guide RNA reduces knockin efficiency and drastically increases on-target large deletions

Chenouard, V., Leray, I., Tesson, L., Remy, S., Allan, A., Archer, D., Caulder, A., Fortun, A., Bernardeau, K., Cherifi, Y., Teboul, L., David, L., Anegon, I.

(2023) , iScience , 26 , 106399

10.1016/j.isci.2023.106399

PMC10074149

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Sectioning and Counting of Motor Neurons in the L3 to L6 Region of the Adult Mouse Spinal Cord

Austin, A., Beresford, L., Price, G., Cunningham, T., Kalmar, B., Yon, M.

(2022) , Curr Protoc , 2 , e428

10.1002/cpz1.428

35617451

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