Methods Development
The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.
Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease
Bains, R. S., Forrest, H., Sillito, R. R., Armstrong, J. D., Stewart, M., Nolan, P. M., Wells, S. E.
Genotyping Genome-Edited Founders and Subsequent Generation
Mackenzie, M., Fower, A., Allan, A. J., Codner, G. F., Bunton-Stasyshyn, R. K., Teboul, L.
Excess of guide RNA reduces knockin efficiency and drastically increases on-target large deletions
Chenouard, V., Leray, I., Tesson, L., Remy, S., Allan, A., Archer, D., Caulder, A., Fortun, A., Bernardeau, K., Cherifi, Y., Teboul, L., David, L., Anegon, I.
Sectioning and Counting of Motor Neurons in the L3 to L6 Region of the Adult Mouse Spinal Cord
Austin, A., Beresford, L., Price, G., Cunningham, T., Kalmar, B., Yon, M.