Methods Development
The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.
Of Mice and Mates: Automated Classification and Modelling of Mouse Behaviour in Groups Using a Single Model Across Cages
Camilleri, M. P. J., Bains, R. S., Williams, C. K. I.
Long-read sequencing for fast and robust identification of correct genome-edited alleles: PCR-based and Cas9 capture methods
McCabe, C. V., Price, P. D., Codner, G. F., Allan, A. J., Caulder, A., Christou, S., Loeffler, J., Mackenzie, M., Malzer, E., Mianné, J., Nowicki, K. J., O'Neill, E. J., Pike, F. J., Hutchison, M., Petit-Demoulière, B., Stewart, M. E., Gates, H., Wells, S., Sanderson, N. D., Teboul, L.
Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease
Bains, R. S., Forrest, H., Sillito, R. R., Armstrong, J. D., Stewart, M., Nolan, P. M., Wells, S. E.
Genotyping Genome-Edited Founders and Subsequent Generation
Mackenzie, M., Fower, A., Allan, A. J., Codner, G. F., Bunton-Stasyshyn, R. K., Teboul, L.