Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Microhomologies are prevalent at Cas9-induced larger deletions

Owens, D. D. G., Caulder, A., Frontera, V., Harman, J. R., Allan, A. J., Bucakci, A., Greder, L., Codner, G. F., Hublitz, P., McHugh, P. J., Teboul, L., de Bruijn, MFTR

(2019) , Nucleic Acids Res , 47 , 7402-7417

10.1093/nar/gkz459

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Response to “Unexpected mutations after CRISPR-Cas9 editing in vivo”

Nutter, L. M. J., Heaney, J. D., Lloyd, K. C. K., Murray, S. A., Seavitt, J. R., Skarnes, W. C., Teboul, L., Brown, S. D. M., Moore, M.

(2018) , Nat Methods , 15 , 235-236

10.1038/nmeth.4559

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Long term maintenance of frozen mouse spermatozoa at -80 degrees C

Raspa, M., Fray, M., Paoletti, R., Montoliu, L., Giuliani, A., Scavizzi, F.

(2018) , Theriogenology , 107 , 41-49

10.1016/j.theriogenology.2017.10.036

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High-throughput mouse phenomics for characterizing mammalian gene function

Brown, S. D. M., Holmes, C. C., Mallon, A. M., Meehan, T. F., Smedley, D., Wells, S.

(2018) , Nat Rev Genet , 19 , 357-370

10.1038/s41576-018-0005-2

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CRISPR-Cas9-Mediated Mutagenesis: Mind the Gap?

Teboul, L., Greenfield, A.

(2018) , The CRISPR Journal , 1 , 263-264

10.1089/crispr.2018.29027

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