Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Phenotyping in Mice Using Continuous Home Cage Monitoring and Ultrasonic Vocalization Recordings

Hobson, L., Bains, R. S., Greenaway, S., Wells, S., Nolan, P. M.

(2020) , Curr Protoc Mouse Biol , 10 , e80

10.1002/cpmo.80

32813317

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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Swan, A. L., Schütt, C., Rozman, J., Del Mar Muñiz Moreno, M., Brmaier, S., Simon, M., Leuchtenberger, S., Griffiths, M., Brommage, R., Keskivali-Bond, P., Grallert, H., Werner, T., Teperino, R., Becker, L., Miller, G., Moshiri, A., Seavitt, J. R., Cissell, D. D., Meehan, T. F., Acar, E. F., Lelliott, C. J., Flenniken, A. M., Champy, M. F., Sorg, T., Ayadi, A., Braun, R. E., Cater, H., Dickinson, M. E., Flicek, P., Gallegos, J., Ghirardello, E. J., Heaney, J. D., Jacquot, S., Lally, C., Logan, J. G., Teboul, L., Mason, J., Spielmann, N., McKerlie, C., Murray, S. A., Nutter, L. M. J., Odfalk, K. F., Parkinson, H., Prochazka, J., Reynolds, C. L., Selloum, M., Spoutil, F., Svenson, K. L., Vales, T. S., Wells, S. E., White, J. K., Sedlacek, R., Wurst, W., Lloyd, K. C. K., Croucher, P. I., Fuchs, H., Williams, G. R., Bassett, D., Gailus-Durner, V., Herault, Y., Mallon, A. M., Brown, S. D. M., Mayer-Kuckuk, P., Hrabe de Angelis, M.

(2020) , PLoS Genet , 16 , e1009190

10.1371/journal.pgen.1009190

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Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata

Poirier, C., Hamed, S. B., Garcia-Saldivar, P., Kwok, S. C., Meguerditchian, A., Merchant, H., Rogers, J., Wells, S., Fox, A. S.

(2020) , Neuroimage , 228 , 117679

10.1016/j.neuroimage.2020.117679

PMC7903159

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Anticipating and Identifying Collateral Damage in Genome Editing

Burgio, G., Teboul, L.

(2020) , Trends Genet , 36 , 905-914

10.1016/j.tig.2020.09.011

PMC7658041

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When all is not lost: considering genetic compensation in laboratory animals

Bunton-Stasyshyn, R. K. A., Wells, S., Teboul, L.

(2019) , Lab Anim , 48 , 282-284

10.1038/s41684-019-0397-4

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