Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

PKD1L1 Is Involved in Congenital Chylothorax

Whitchurch, J. B., Schneider, S., Hilger, A. C., Köllges, R., Stegmann, J. D., Waffenschmidt, L., Dyer, L., Thiele, H., Dhabhai, B., Dakal, T. C., Müller, A., Norris, D. P., Reutter, H. M.

(2024) , Cells , 13 , 149

10.3390/cells13020149

38247840

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TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system

Akula, S. K., Marciano, J. H., Lim, Y., Exposito-Alonso, D., Hylton, N. K., Hwang, G. H., Neil, J. E., Dominado, N., Bunton-Stasyshyn, R. K., Song, J. H. T., Talukdar, M., Schmid, A., Teboul, L., Mo, A., Shin, T., Finander, B., Beck, S. G., Yeh, R. C., Otani, A., Qian, X., DeGennaro, E. M., Alkuraya, F. S., Maddirevula, S., Cascino, G. D., Giannini, C., Burrage, L. C., Rosenfield, J. A., Ketkar, S., Clark, G. D., Bacino, C., Lewis, R. A., Segal, R. A., Bazan, J. F., Smith, K. A., Golden, J. A., Cho, G., Walsh, C. A.

(2023) , Proc Natl Acad Sci U S A , 120 , e2209964120

10.1073/pnas.2209964120

36669111

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Tissue specific differences in the assembly of mitochondrial complex I is revealed by a novel ENU mutation in ECSIT

Nicol, T. Falcone, S. Blease, A. Vikhe, P. Civiletto, G. Omairi, S. S. Viscomi, C. Patel, K. Potter, P. K.

(2023) , Cardiovasc Res , 119 , 2213-2229

10.1093/cvr/cvad101

37395010

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The parenting hub of the hypothalamus is a focus of imprinted gene action

Higgs, M. J., Webberley, A. E., Allan, A. J., Talat, M., John, R. M., Isles, A. R.

(2023) , PLoS Genet , 19 , e1010961

10.1371/journal.pgen.1010961

PMC10586610

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Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

Brown, N., Finnon, R., Finnon, P., McCarron, R., Cruz-Garcia, L., O'Brien, G., Herbert, E., Scudamore, C. L., Morel, E., Badie, C.

(2023) , iScience , 26 , 107530

10.1016/j.isci.2023.107530

PMC10469541

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