Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

AKR1D1 knockout mice develop a sex dependent metabolic phenotype

Gathercole, L. L., Nikolaou, N., Harris, S. E., Arvaniti, A., Poolman, T. M., Hazlehurst, J. M., Kratschmar, D. V., Todorcevic, M., Moolla, A., Dempster, N., Pink, R. C., Saikali, M. F., Bentley, L., Penning, T. M., Ohlsson, C., Cummins, C. L., Poutanen, M., Odermatt, A., Cox, R. D., Tomlinson, J. W.

(2022) , J Endocrinol , 253 , 97-113

10.1530/joe-21-0280

PMC9086936

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A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning

Mušo, M., Bentley, L., Vizor, L., Yon, M., Burling, K., Barker, P., Zolkiewski, L. A. K., Cox, R. D., Dumbell, R.

(2022) , Front Physiol , 13 , 953199

10.3389/fphys.2022.953199

PMC9452902

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Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis

Wu, Y., Bai, Y., McEwan, D. G., Bentley, L., Aravani, D., Cox, R. D.

(2021) , Biol Open , 10 , bio058420

10.1242/bio.058420

PMC8689486

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Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Wells, S., Cox, R. D., Gibbins, J. M., Sellayah, D., C, E. Hughes

(2021) , Sci Rep , 11 , 1473

10.1038/s41598-020-80373-3

PMC7809045

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Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

Muha, V., Authier, F., Szoke-Kovacs, Z., Johnson, S., Gallagher, J., McNeilly, A., McCrimmon, R. J., Teboul, L., van Aalten, D. M. F.

(2021) , J Biol Chem , 296 , 100439

10.1016/j.jbc.2021.100439

PMC7988489

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