Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Absence of Embigin accelerates hearing loss and causes sub-viability, brain and heart defects in C57BL/6N mice due to interaction with Cdh23(ahl)
Newton, S., Aguilar, C., Bunton-Stasyshyn, R. K., Flook, M., Stewart, M., Marcotti, W., Brown, S., Bowl, M. R.
A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (NFIX) Gene Has Phenotypic Features of Marshall-Smith Syndrome
Kooblall, K. G., Stevenson, M., Stewart, M., Harris, L., Zalucki, O., Dewhurst, H., Butterfield, N., Leng, H., Hough, T. A., Ma, D., Siow, B., Potter, P., Cox, R. D., Brown, S. D. M., Horwood, N., Wright, B., Lockstone, H., Buck, D., Vincent, T. L., Hannan, F. M., Bassett, J. H. D., Williams, G. R., Lines, K. E., Piper, M., Wells, S., Teboul, L., Hennekam, R. C., Thakker, R. V.
A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice
Nolan, P. M., Banks, G., Bourbia, N., Wilcox, A. G., Bentley, L., Moir, L., Kent, L., Hillier, R., Wilson, D., Barrett, P., Dumbell, R.
TissUExM enables quantitative ultrastructural analysis in whole vertebrate embryos by expansion microscopy
Steib, E., Tetley, R., Laine, R.F., Norris, D.P., Mao, Y., Vermot, J.
Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation
Khalil, Y., Carrino, S., Lin, F., Ferlin, A., Lad, H. V., Mazzacuva, F., Falcone, S., Rivers, N., Banks, G., Concas, D., Aguilar, C., Haynes, A. R., Blease, A., Nicol, T., Al-Shawi, R., Heywood, W., Potter, P., Mills, K., Gale, D. P., Clayton, P. T.