Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Myosin-based nucleation of actin filaments contributes to stereocilia development critical for hearing
Moreland, Z. G., Jiang, F., Aguilar, C., Barzik, M., Gong, R., Behnammanesh, G., Park, J., Shams, A., Faaborg-Andersen, C., Werth, J. C., Harley, R., Sutton, D. C., Heidings, J. B., Cole, S. M., Parker, A., Morse, S., Wilson, E., Takagi, Y., Sellers, J. R., Brown, S. D. M., Friedman, T. B., Alushin, G. M., Bowl, M. R., Bird, J. E.
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis
Boyanova, S., Banks, G., Lipina, T. V., Bains, R. S., Forrest, H., Stewart, M., Carcolé, M., Milioto, C., Isaacs, A. M., Wells, S. E., Wiseman, F. K.
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity
Corrà, S., Zuppardo, A., Valenzuela, S., Jenninger, L., Cerutti, R., Sillamaa, S., Hoberg, E., Johansson, K. A. S., Rovsnik, U., Volta, S., Silva-Pinheiro, P., Davis, H., Trifunovic, A., Minczuk, M., Gustafsson, C. M., Suomalainen, A., Zeviani, M., Macao, B., Zhu, X., Falkenberg, M., Viscomi, C.
Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age
Oestereicher, M. A., Ward, C. S., Schneltzer, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Bou About, G., Selloum, M., Meziane, H., Stewart, M., Teboul, L., Norris, C., Pimm, D., Kan, M., López Gómez, F., Wilson, R., Monroy, M., Pasha, S., Zabrodska, E., Prochazka, J., Pajuelo Reguera, D., Nichtova, Z., Herault, Y., Wells, S., Parkinson, H., Heaney, J. D., Sedlacek, R., Gao, X., Hrabe de Angelis, M., Spielmann, N.
CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern
Giese, A. P. J., Parker, A., Rehman, S., Brown, S. D. M., Riazuddin, S., Kooi, C. W. V., Bowl, M. R., Ahmed, Z. M.