Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

Investigating audible and ultrasonic noise in modern animal facilities

Parker, A., Hobson, L., Bains, R., Wells, S., Bowl, M.

(2022) , F1000Res , 11 , 651

10.12688/f1000research.111170.1

PMC9334837

View Full Paper


Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen

Wotton, J. M., Peterson, E., Flenniken, A. M., Bains, R. S., Veeraragavan, S., Bower, L. R., Bubier, J. A., Parisien, M., Bezginov, A., Haselimashhadi, H., Mason, J., Moore, M. A., Stewart, M. E., Clary, D. A., Delbarre, D. J., Anderson, L. C., D'Souza, A., Goodwin, L. O., Harrison, M. E., Huang, Z., McKay, M., Qu, D., Santos, L., Srinivasan, S., Urban, R., Vukobradovic, I., Ward, C. S., Willett, A. M., Braun, R. E., Brown, S. D. M., Dickinson, M. E., Heaney, J. D., Kumar, V., Lloyd, K. C. K., Mallon, A. M., McKerlie, C., Murray, S. A., Nutter, L. M. J., Parkinson, H., Seavitt, J. R., Wells, S., Samaco, R. C., Chesler, E. J., Smedley, D., Diatchenko, L., Baumbauer, K. M., Young, E. E., Bonin, R. P., Mandillo, S., White, J. K.

(2022) , Pain , 163 , 1139-1157

10.1097/j.pain.0000000000002481

PMC9100450

View Full Paper


Gadd45g is required for timely Sry expression independently of RSPO1 activity

Warr, N., Siggers, P., May, J., Chalon, N., Pope, M., Wells, S., Chaboissier, M. C., Greenfield, A.

(2022) , Reproduction , 163 , 333-340

10.1530/rep-21-0443

PMC9066659

View Full Paper


Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice

Cheng, C., Cleak, J., Weiss, L., Cater, H., Stewart, M., Wells, S., Columbres, R. C., Shmara, A., Morato Torres, C. A., Zafar, F., Schüle, B., Neumann, J., Hatchwell, E., Kimonis, V.

(2022) , Orphanet J Rare Dis , 17 , 386

10.1186/s13023-022-02446-y

PMC9594925

View Full Paper


Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities

Leslie, J. S., Hjeij, R., Vivante, A., Bearce, E. A., Dyer, L., Wang, J., Rawlins, L., Kennedy, J., Ubeyratna, N., Fasham, J., Irons, Z. H., Craig, S. B., Koenig, J., George, S., Pode-Shakked, B., Bolkier, Y., Barel, O., Mane, S., Frederiksen, K. K., Wenger, O., Scott, E., Cross, H. E., Lorentzen, E., Norris, D. P., Anikster, Y., Omran, H., Grimes, D. T., Crosby, A. H., Baple, E. L.,

(2022) , Genet Med , ,

10.1016/j.gim.2022.07.019

36074124

View Full Paper


1 2 3 4 17