Methods Development
The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.
Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control
Mianne, J., Codner, G. F., Caulder, A., Fell, R., Hutchison, M., King, R., Stewart, M. E., Wells, S., Teboul, L.
Intestinal Preparation Techniques for Histological Analysis in the Mouse
Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., Pritchard, D. M.
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
Haeussler, M., Schonig, K., Eckert, H., Eschstruth, A., Mianne, J., Renaud, J. B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., Joly, J. S., Concordet, J. P.
Building for the future: essential infrastructure for rodent ageing studies
Wells, S. E., Bellantuono, I.
Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction
Codner, G. F., Lindner, L., Caulder, A., Wattenhofer-Donze, M., Radage, A., Mertz, A., Eisenmann, B., Mianne, J., Evans, E. P., Beechey, C. V., Fray, M. D., Birling, M. C., Herault, Y., Pavlovic, G., Teboul, L.