Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease

Bhalla, S. R., Wahid, M., Amartey, J. O., Zawia, A., Riu, F., Gao, Y., Agrawal, J., Lynch, A. P., Machado, M. J., Hawtrey, T., Kikuchi, R., Green, K. R., Teboul, L., Allen, C. L., Blackley, Z., Rajaji, K., Batson, J., Harper, S. J., Oltean, S., Amoaku, W., Benest, A. V., Morris, J. C., Braithwaite, B., Bates, D. O.

(2025) , Am J Physiol Heart Circ Physiol , 329 , H490-H504

10.1152/ajpheart.00564.2024

40588360

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Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

Briere, A., Vo, P., Yang, B., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Brown, S. D. M., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Hérault, Y., Hrabe de Angelis, M., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Salazar, J., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Wells, S., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.

(2025) , Invest Ophthalmol Vis Sci , 66 , 7

10.1167/iovs.66.5.7

PMC12060066

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Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes

Vo, P., Imai-Leonard, D. M., Yang, B., Briere, A., Shao, A., Casanova, M. I., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Braun, R., Brown, S., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Dickinson, M., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Heaney, J., Hérault, Y., Angelis, M. H., Hsu, C. W., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Murray, S., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Ryan, J., Salazar, J., Seavey, Z., Seavitt, J. R., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Udensi, U., Wells, S., White, J., Willett, A., Wotton, J., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.

(2025) , BMC Genomics , 26 , 48

10.1186/s12864-025-11222-8

PMC11744888

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Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes

Hang, A., Shao, A., Shea, M., Roux, M. J., Imai-Leonard, D. M., Adams, D. J., Amano, T., Amarie, O. V., Berberovic, Z., Bour, R., Bower, L., Leonard, B. C., Brown, S. D., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A. J., Dickinson, M., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Heaney, J., Hérault, Y., Hrabe de Angelis, M., Hsu, C. W., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Salazar, J., Seavitt, J. R., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Sorg, T., Stewart, M., Tamura, M., Tolentino, H., Udensi, U., Wells, S., Wurst, W., Yoshiki, A., Meziane, H., Yiu, G., Sieving, P. A., Lanoue, L., Lloyd, K. C. K., McKerlie, C., Moshiri, A.

(2025) , Invest Ophthalmol Vis Sci , 66 , 64

10.1167/iovs.66.6.64

PMC12186831

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Myosin-based nucleation of actin filaments contributes to stereocilia development critical for hearing

Moreland, Z. G., Jiang, F., Aguilar, C., Barzik, M., Gong, R., Behnammanesh, G., Park, J., Shams, A., Faaborg-Andersen, C., Werth, J. C., Harley, R., Sutton, D. C., Heidings, J. B., Cole, S. M., Parker, A., Morse, S., Wilson, E., Takagi, Y., Sellers, J. R., Brown, S. D. M., Friedman, T. B., Alushin, G. M., Bowl, M. R., Bird, J. E.

(2025) , Nat Commun , 16 , 947

10.1038/s41467-025-55898-8

PMC11754657

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