Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies
Briere, A., Vo, P., Yang, B., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Brown, S. D. M., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Hérault, Y., Hrabe de Angelis, M., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Salazar, J., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Wells, S., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes
Vo, P., Imai-Leonard, D. M., Yang, B., Briere, A., Shao, A., Casanova, M. I., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Braun, R., Brown, S., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Dickinson, M., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Heaney, J., Hérault, Y., Angelis, M. H., Hsu, C. W., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Murray, S., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Ryan, J., Salazar, J., Seavey, Z., Seavitt, J. R., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Udensi, U., Wells, S., White, J., Willett, A., Wotton, J., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.
Myosin-based nucleation of actin filaments contributes to stereocilia development critical for hearing
Moreland, Z. G., Jiang, F., Aguilar, C., Barzik, M., Gong, R., Behnammanesh, G., Park, J., Shams, A., Faaborg-Andersen, C., Werth, J. C., Harley, R., Sutton, D. C., Heidings, J. B., Cole, S. M., Parker, A., Morse, S., Wilson, E., Takagi, Y., Sellers, J. R., Brown, S. D. M., Friedman, T. B., Alushin, G. M., Bowl, M. R., Bird, J. E.
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity
Corrà, S., Zuppardo, A., Valenzuela, S., Jenninger, L., Cerutti, R., Sillamaa, S., Hoberg, E., Johansson, K. A. S., Rovsnik, U., Volta, S., Silva-Pinheiro, P., Davis, H., Trifunovic, A., Minczuk, M., Gustafsson, C. M., Suomalainen, A., Zeviani, M., Macao, B., Zhu, X., Falkenberg, M., Viscomi, C.
CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern
Giese, A. P. J., Parker, A., Rehman, S., Brown, S. D. M., Riazuddin, S., Kooi, C. W. V., Bowl, M. R., Ahmed, Z. M.