Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease
Bhalla, S. R., Wahid, M., Amartey, J. O., Zawia, A., Riu, F., Gao, Y., Agrawal, J., Lynch, A. P., Machado, M. J., Hawtrey, T., Kikuchi, R., Green, K. R., Teboul, L., Allen, C. L., Blackley, Z., Rajaji, K., Batson, J., Harper, S. J., Oltean, S., Amoaku, W., Benest, A. V., Morris, J. C., Braithwaite, B., Bates, D. O.
Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies
Briere, A., Vo, P., Yang, B., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Brown, S. D. M., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Hérault, Y., Hrabe de Angelis, M., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Salazar, J., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Wells, S., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes
Vo, P., Imai-Leonard, D. M., Yang, B., Briere, A., Shao, A., Casanova, M. I., Adams, D., Amano, T., Amarie, O., Berberovic, Z., Bower, L., Braun, R., Brown, S., Burrill, S., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A., Dickinson, M., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Heaney, J., Hérault, Y., Angelis, M. H., Hsu, C. W., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Meziane, H., Murray, S., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Ryan, J., Salazar, J., Seavey, Z., Seavitt, J. R., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Stewart, M., Svenson, K., Tamura, M., Tolentino, H., Udensi, U., Wells, S., White, J., Willett, A., Wotton, J., Wurst, W., Yoshiki, A., Lanoue, L., Lloyd, K. C. K., Leonard, B. C., Roux, M. J., McKerlie, C., Moshiri, A.
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes
Hang, A., Shao, A., Shea, M., Roux, M. J., Imai-Leonard, D. M., Adams, D. J., Amano, T., Amarie, O. V., Berberovic, Z., Bour, R., Bower, L., Leonard, B. C., Brown, S. D., Cho, S. Y., Clementson-Mobbs, S., D'Souza, A. J., Dickinson, M., Eskandarian, M., Flenniken, A. M., Fuchs, H., Gailus-Durner, V., Heaney, J., Hérault, Y., Hrabe de Angelis, M., Hsu, C. W., Jin, S., Joynson, R., Kang, Y. K., Kim, H., Masuya, H., Nam, K. H., Noh, H., Nutter, L. M. J., Palkova, M., Prochazka, J., Raishbrook, M. J., Riet, F., Salazar, J., Seavitt, J. R., Sedlacek, R., Selloum, M., Seo, K. Y., Seong, J. K., Shin, H. S., Shiroishi, T., Sorg, T., Stewart, M., Tamura, M., Tolentino, H., Udensi, U., Wells, S., Wurst, W., Yoshiki, A., Meziane, H., Yiu, G., Sieving, P. A., Lanoue, L., Lloyd, K. C. K., McKerlie, C., Moshiri, A.
Myosin-based nucleation of actin filaments contributes to stereocilia development critical for hearing
Moreland, Z. G., Jiang, F., Aguilar, C., Barzik, M., Gong, R., Behnammanesh, G., Park, J., Shams, A., Faaborg-Andersen, C., Werth, J. C., Harley, R., Sutton, D. C., Heidings, J. B., Cole, S. M., Parker, A., Morse, S., Wilson, E., Takagi, Y., Sellers, J. R., Brown, S. D. M., Friedman, T. B., Alushin, G. M., Bowl, M. R., Bird, J. E.