Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations
Bryant, D., Seda, M., Peskett, E., Maurer, C., Pomeranz, G., Ghosh, M., Hawkins, T. A. Cleak, J., Datta, S., Hariri, H., Eckert, K. M., Jafree, D. J., Walsh, C., Demetriou, C., Ishida, M., Alemán-Charlet, C., Vestito, L., Seselgyte, R., McDonald, J. G., Bitner-Glindzicz, M., Hemberger, M., Rihel, J., Teboul, L., Henne, W. M., Jenkins, D., Moore, G. E., Stanier, P.
Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells
Jeng, J. Y., Johnson, S. L., Carlton, A. J., De Tomasi, L., Goodyear, R. J., De Faveri, F., Furness, D. N., Wells, S., Brown, S. D. M., Holley, M. C., Richardson, G. P., Mustapha, M., Bowl, M. R., Marcotti, W.
The development of a high throughput drug-responsive model of white adipose tissue comprising adipogenic 3T3-L1 cells in a 3D matrix
Graham, A. D., Pandey, R., Tsancheva, V. S., Candeo, A., Botchway, S. W., Allan, A. J., Teboul, L., Madi, K., Babra, T. S., Zolkiewski, L. A. K., Xue, X., Bentley, L., Gannon, J., Olof, S. N., Cox, R. D.
Mice With a Brd4 Mutation Represent a New Model of Nephrocalcinosis
Gorvin, C. M., Loh, N. Y., Stechman, M. J., Falcone, S., Hannan, F. M., Ahmad, B. N., Piret, S. E., Reed, A. A., Jeyabalan, J., Leo, P., Marshall, M., Sethi, S., Bass, P., Roberts, I., Sanderson, J., Wells, S., Hough, T. A., Bentley, L., Christie, P. T., Simon, M. M., Mallon, A. M., Schulz, H., Cox, R. D., Brown, M. A., Huebner, N., Brown, S. D., Thakker, R. V.
Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight
Livermore, C., Warr, N., Chalon, N., Siggers, P., Mianne, J., Codner, G., Teboul, L., Wells, S., Greenfield, A.