Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities
Stewart, M., Lau, P., Banks, G., Bains, R. S., Castroflorio, E., Oliver, P. L., Dixon, C. L., Kruer, M. C., Kullmann, D. M., Acevedo-Arozena, A., Wells, S. E., Corrochano, S., Nolan, P. M.
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
Haq, N., Schmidt-Hieber, C., Sialana, F. J., Ciani, L., Heller, J. P., Stewart, M., Bentley, L., Wells, S., Rodenburg, R. J., Nolan, P. M., Forsythe, E., Wu, M. C., Lubec, G., Salinas, P., Hausser, M., Beales, P. L., Christou-Savina, S.
Clarin-2 is essential for hearing by maintaining stereocilia integrity and function
Dunbar, L. A., Patni, P., Aguilar, C., Mburu, P., Corns, L., Wells, H. R., Delmaghani, S., Parker, A., Johnson, S., Williams, D., Esapa, C. T., Simon, M. M., Chessum, L., Newton, S., Dorning, J., Jeyarajan, P., Morse, S., Lelli, A., Codner, G. F., Peineau, T., Gopal, S. R., Alagramam, K. N., Hertzano, R., Dulon, D., Wells, S., Williams, F. M., Petit, C., Dawson, S. J., Brown, S. D., Marcotti, W., El-Amraoui, A., Bowl, M. R.
An N-ethyl-N-nitrosourea (ENU)-induced Tyr265Stop mutation of the DNA polymerase accessory subunit gamma 2 (Polg2) is associated with renal calcification in mice
Gorvin, C. M., Ahmad, B. N., Stechman, M. J., Loh, N. Y., Hough, T. A., Leo, P., Marshall, M., Sethi, S., Bentley, L., Piret, S. E., Reed, A., Jeyabalan, J., Christie, P. T., Wells, S., Simon, M. M., Mallon, A. M., Schulz, H., Huebner, N., Brown, M. A., Cox, R. D., Brown, S. D., Thakker, R. V.
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling
Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, D. T., Suzuki, M., Burdine, R. D., Cong, F., Koo, B. K., Clevers, H., Stevant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A.