Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Mutant mice with calcium-sensing receptor (CaSR) activation have hyperglycemia, that is rectified by calcilytic therapy
Babinsky, V. N., Hannan, F. M., Ramracheya, R. D., Zhang, Q., Nesbit, M. A., Hugill, A., Bentley, L., Hough, T. A., Joynson, E., Stewart, M., Aggarwal, A., Prinz-Wohlgenannt, M., Gorvin, C. M., Kallay, E., Wells, S., Cox, R. D., Richards, D., Rorsman, P., Thakker, R. V.
Intrauterine air impairs embryonic postimplantation development in mice
Liu, R., Li, Y., Miao, Y., Wei, Y., Guan, M., Zhou, R., Li, X.
Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in ‘FUSDelta14’ knockin mice
Devoy, A., Kalmar, B., Stewart, M., Park, H., Burke, B., Noy, S. J., Redhead, Y., Humphrey, J., Lo, K., Jaeger, J., Mejia Maza, A., Sivakumar, P., Bertolin, C., Soraru, G., Plagnol, V., Greensmith, L., Acevedo Arozena, A., Isaacs, A. M., Davies, B., Fratta, P., Fisher, E. M. C.
Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy
Gorvin, C. M., Hannan, F. M., Howles, S. A., Babinsky, V. N., Piret, S. E., Rogers, A., Freidin, A. J., Stewart, M., Paudyal, A., Hough, T. A., Nesbit, M. A., Wells, S., Vincent, T. L., Brown, S. D., Cox, R. D., Thakker, R. V.
Does age matter? The impact of rodent age on study outcomes
Jackson, S. J., Andrews, N., Ball, D., Bellantuono, I., Gray, J., Hachoumi, L., Holmes, A., Latcham, J., Petrie, A., Potter, P., Rice, A., Ritchie, A., Stewart, M., Strepka, C., Yeoman, M., Chapman, K.