Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity
Possamai, L. A., McPhail, M. J., Khamri, W., Wu, B., Concas, D., Harrison, M., Williams, R., Cox, R. D., Cox, I. J., Anstee, Q. M., Thursz, M. R.
The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis
Parsons, M. J., Brancaccio, M., Sethi, S., Maywood, E. S., Satija, R., Edwards, J. K., Jagannath, A., Couch, Y., Finelli, M. J., Smyllie, N. J., Esapa, C., Butler, R., Barnard, A. R., Chesham, J. E., Saito, S., Joynson, G., Wells, S., Foster, R. G., Oliver, P. L., Simon, M. M., Mallon, A. M., Hastings, M. H., Nolan, P. M.
Pharmacological Inhibition of FTO
McMurray, F., Demetriades, M., Aik, W., Merkestein, M., Kramer, H., Andrew, D. S., Scudamore, C. L., Hough, T. A., Wells, S., Ashcroft, F. M., McDonough, M. A., Schofield, C. J., Cox, R. D.
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic beta Cells
Arredouani, A., Ruas, M., Collins, S. C., Parkesh, R., Clough, F., Pillinger, T., Coltart, G., Rietdorf, K., Royle, A., Johnson, P., Braun, M., Zhang, Q., Sones, W., Shimomura, K., Morgan, A. J., Lewis, A. M., Chuang, K. T., Tunn, R., Gadea, J., Teboul, L., Heister, P. M., Tynan, P. W., Bellomo, E. A., Rutter, G. A., Rorsman, P., Churchill, G. C., Parrington, J., Galione, A.
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance
Hugill, A. J., Stewart, M. E., Yon, M. A., Probert, F., Cox, I. J., Hough, T. A., Scudamore, C. L., Bentley, L., Wall, G., Wells, S. E., Cox, R. D.