Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues
Al-Jazzar, A., Javaheri, B., Prideaux, M., Boyde, A., Scudamore, C. L., Cherifi, C., Hay, E., Hopkinson, M., Boyd, M., Cohen-Solal, M., Farquharson, C., Pitsillides, A. A.
Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
Joyce, P. I., Fratta, P., Landman, A. S., McGoldrick, P., Wackerhage, H., Groves, M., Busam, B. S., Galino, J., Corrochano, S., Beskina, O. A., Esapa, C., Ryder, E., Carter, S., Stewart, M., Codner, G., Hilton, H., Teboul, L., Tucker, J., Lionikas, A., Estabel, J., Ramirez-Solis, R., White, J. K., Brandner, S., Plagnol, V., Bennet, D. L., Abramov, A. Y., Greensmith, L., Fisher, E. M., Acevedo-Arozena, A.
Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair
Mianne, J., Chessum, L., Kumar, S., Aguilar, C., Codner, G., Hutchison, M., Parker, A., Mallon, A. M., Wells, S., Simon, M. M., Teboul, L., Brown, S. D., Bowl, M. R.
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model
Spiers, H., Hannon, E., Wells, S., Williams, B., Fernandes, C., Mill, J.
Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss
Carrott, L., Bowl, M. R., Aguilar, C., Johnson, S. L., Chessum, L., West, M., Morse, S., Dorning, J., Smart, E., Hardisty-Hughes, R., Ball, G., Parker, A., Barnard, A. R., MacLaren, R. E., Wells, S., Marcotti, W., Brown, S. D.