David Thompson

I am interested in the genetics and pathological mechanisms of amyotrophic lateral sclerosis (ALS). Current treatment options for ALS are severely limited, with approved drugs only offering a modest prolongation of survival. The lack of effective treatments for ALS persists in spite of significant research progress in the field, reflecting the difficulties in translating ALS research findings into effective treatments for patients. Improved translation will require the generation of new models which more closely recapitulate human ALS. My research focuses on the development and characterisation of so-called ‘humanised’ mouse models of ALS, in the hope that these models will provide better insights into ALS pathogenesis.

I received my MSci (Hons) in Natural Sciences from the University of Bath in 2018. While studying at Bath I also completed a year-long research internship with Professor Marina Picciotto at the Yale School of Medicine, studying the role of the cholinergic system in anxiety and depression. Subsequently, I worked as a research assistant in the Mouse Models of Neurodegeneration group at the MRC Harwell Institute, where I am now continuing my research as a DPhil student.