Dominic Simpson

Oxidative stress in the CNS is implicated in various neurological disorders, including dementia, psychiatric disorders, epilepsy and autism. The brain has a high metabolic rate, utilising around 20% of the body’s energy, yet has a relatively low antioxidant capacity, thus the brain is especially sensitive to oxidative stress. A family of proteins known as TLDc proteins are important in regulating oxidative stress resistance in the brain and mutations in these proteins can cause seizures, neurodegeneration and hearing loss. Our group aims to characterise how these proteins regulate oxidative stress and other vital processes in the CNS using mouse models of human disease. I am especially interested in how TLDc proteins regulate the neuroinflammatory response in the brain, a process closely related to oxidative stress, and also implicated in a host of neurological diseases.

I attained integrated degrees of BSc, MBiol in Medical Science from the University of Leeds in 2019 and am a current DPhil student at MRC Harwell and the University of Oxford