Grace Zhuo Yu

Biography & Research interests

I am currently a postdoctoral scientist in Professor Roger Cox’s group. I am also a postdoc scientist in Professor Anna Gloyn and Mark McCarthy’s research group at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM); and an Associate Research Fellow at Harbin Medical University, China. My current research focuses on trying to understand the molecular mechanisms by which coding and non-coding changes in genomic sequences affect gene regulation and protein function in Type II Diabetes.

I previously worked as a postdoctoral researcher in the RDM Division of Cardiovascular Medicine, University of Oxford. My earlier research focused on the role of genetics and early environment in the development of cardiovascular disease.

Current Projects

  1. RREB1 project – understanding the role of RREB1 in adipose tissue and pancreas to the risk of ectopic fat distribution and Type II Diabetes.

Selected Publications

Yu, G. Z, Reilly, S, Lewandowski, A. J, Aye, C. Y. L, Simpson, L. J, Newton, L, Davis, E. F, Zhu, S. J, Fox, W. R, Goel, A, Watkins, H, Channon, K. M, Watt, S. M, Kyriakou, T, Leeson, P. Neonatal Micro-RNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies. Hypertension. 2018 Oct;72(4):937-45

Yu, G, Leeson P. Hypertensive Pregnancy: A Cardiovascular Risk Marker for the Whole Family? Nat Rev Nephrol. 2017

Yu, G, Aye C, Lewandowski AJ, Davis EF, K Cheen, Newton L, Cheng TY, Zen A, Simpson L, O’Brien K, Cook DA, Kyriakou T, Channon K, Watt S, Leeson P. Association of maternal anti-angiogenic profile at birth with early postnatal loss of microvascular density in offspring of hypertensive pregnancies. Hypertension. 2016 Sep;68(3):749-59