Laura Dyer - PhD

I began my PhD here at the MRC Harwell Institute in October 2017, and joined the Cilia, Development and Disease group run by Dr Dominic Norris. My project involves investigating the ciliary localisation of Polycystins during L-R patterning. We know that Polycystin-2 and Polycystin-1L1 are important for L-R pattern determination, and that Polycycstin-2 is required within nodal cilia; however this process is not fully understood. I aim to unravel the mechanisms driving PC2 ciliary localisation, its function within nodal cilia, and the role PC1L1 plays alongside PC2 for correct L-R pattern determination.

Before starting my PhD, I graduated from Cardiff University with a BSc (Hons) in Biomedical Sciences with Professional Training Year, where I focused my modules on genetics and human disease. My interest for cilia and ciliopathies began during my professional training year, where I went to the UCL Great Ormond Street Institute of Child Health in London and worked on research projects for two ciliopathies – PCD (Primary Ciliary Dyskinesia) and Jeune syndrome.