Minghui Yin

Biography & Research interests

I took an interest in microbiology during my undergraduate degree in Biotechnology. I therefore chose to study Environmental Microbiology as my Master’s degree. My Master’s research project was to establish a cost effective water safety detection method with antibody engineering. During the time in the lab, I received training in molecular and protein research, which invoked my interest in molecular biology and immunology. Therefore, I studied cellular and molecular biology of disease development in a plant model during my PhD in the University of Edinburgh. I started building up my knowledge and skills in genetics, molecular and cell biology. During my PhD studies, I discovered a group of transcription factors involved in the regulation of disease resistance through transcriptome regulation. Since then, I have developed strong interests in understanding disease development at genetic and molecular levels. To continue working and further developing my expertise in my interested area, I joined MRC Harwell, neurobehavioural genetics group in 2016. Hence, I grab the opportunity to expand my research barriers from plant to animal research and neuroscience.

Current Projects

  1. Circadian rhythms are important biological processes that drive the majority of our body functions in rhythms of approximately 24 hours. The disruption of circadian rhythms is associated with a variety of conditions including metabolic disorders and psychiatric diseases. Circadian rhythms are regulated by the master clock in a brain region known as the suprachiasmatic nucleus (SCN) to ensure our normal body functions. My current research focuses primarily on this brain region. Through identifying and characterising the molecular components in the SCN that influence circadian rhythmicity, I can establish a network of circadian regulation to improve diagnosis and therapy of circadian-related diseases.

Selected Publications

Yun, B. W., Feechan, A., Yin, M., Saidi, N. B., Le Bihan, T., Yu, M., . . . Loake, G. J. (2011). S-nitrosylation of NADPH oxidase regulates cell death in plant immunity. Nature, 478(7368), 264-268. doi: 10.1038/nature10427

Yun, B. W., Skelly, M. J., Yin, M., Yu, M., Mun, B. G., Lee, S. U., . . . Loake, G. J. (2016). Nitric oxide and S-nitrosoglutathione function additively during plant immunity. New Phytol, 211(2), 516-526. doi: 10.1111/nph.13903